The Upper East Side of New York is a neighborhood in Manhattan. The area is situated between East River and Central Park. The Upper East Side is the most affluent area of Manhattan. Many upper-class residents of the city call the Upper East Side home. There are 207,533 people residing in this area of Manhattan. The area is safe, beautiful, and filled with all of the charm one could expect in New York City. The area is filled with great culture and beautiful scenery too. The Upper East Side has one subway line for easy access to other areas of the city. The public bus system is also available for transportation in the area. You'll also be able to see the whole area by renting an affordable car from Car Rental Express.